Science and Engineering at The University of Edinburgh

Seminars & Discussions

Week beginning 19 October 2014

Monday 20 Oct 14 - 1:00pm

Lunchtime Seminars

Overview of Disordered Systems and some Progress with the Replica Method

Peter Mottishaw (University of Edinburgh)

This talk will give an overview of some of the ideas that have proved useful in understanding disordered systems. It will then describe some progress in understanding the replica method in the context of the random energy model, the simplest disordered system where replica symmetry is broken. Disordered systems include materials such as glasses and spin glasses. Problems outside of physics, such as classic optimisation problems, neural networks and genealogy models, can also be considered as disordered systems and have been addressed using replicas and other techniques.

Friday 24 Oct 14 - 11:30am - JCMB 2511

Journal Club

Membrane Binding of MinE Allows for a Comprehensive Description of Min-Protein Pattern Formation

Authors: Mike Bonny, Elisabeth Fischer-Friedrich, Martin Loose, Petra Schwille, Karsten Kruse

Speaker: Chay Paterson

The rod-shaped bacterium Escherichia coli selects the cell center as site of division with the help of the proteins MinC, MinD, and MinE. This protein system collectively oscillates between the two cell poles by alternately binding to the membrane in one of the two cell halves. This dynamic behavior, which emerges from the interaction of the ATPase MinD and its activator MinE on the cell membrane, has become a paradigm for protein self-organization. Recently, it has been found that not only the binding of MinD to the membrane, but also interactions of MinE with the membrane contribute to Min-protein selforganization. Here, we show that by accounting for this finding in a computational model, we can comprehensively describe all observed Min-protein patterns in vivo and in vitro. Furthermore, by varying the system's geometry, our computations predict patterns that have not yet been reported. We confirm these predictions experimentally.
PLOS Computational Biology 9 article e1003347 (2013)
pdf version

Upcoming meetings

Monday 27 Oct 14 - 1:00pm - Room 2511

Lunchtime Seminars

Confirmed

Dongyu Cai (University of Edinburgh)

Friday 31 Oct 14 - 11:30am - JCMB 2511

Journal Club

To be confirmed

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