The journal club is intended to be a weekly natter about interesting recent research. We tend to stick to high-impact journals - Nature, Science, PNAS and PRL have been popular - but this is not prescriptive. Given the diversity of research in the CM group, chosen topics vary widely. Anyone and everyone is welcome: if you have a paper you want to discuss, email it to me (Joe Tavacoli
) and I'll slot you in.
Week beginning 19 October 2014
Friday 24 Oct 14 - 11:30am - JCMB 2511
Membrane Binding of MinE Allows for a Comprehensive Description of Min-Protein Pattern Formation
Authors: Mike Bonny, Elisabeth Fischer-Friedrich, Martin Loose, Petra Schwille, Karsten Kruse
Speaker: Chay Paterson
The rod-shaped bacterium Escherichia coli
selects the cell center as site of division with the help of the proteins MinC, MinD, and MinE. This protein system collectively oscillates between the two cell poles by alternately binding to the membrane in one of the two cell halves. This dynamic behavior, which emerges from the interaction of the ATPase MinD and its activator MinE on the cell membrane, has become a paradigm for protein self-organization. Recently, it has been found that not only the binding of MinD to the membrane, but also interactions of MinE with the membrane contribute to Min-protein selforganization. Here, we show that by accounting for this finding in a computational model, we can comprehensively describe all observed Min-protein patterns in vivo
and in vitro
. Furthermore, by varying the system's geometry, our computations predict patterns that have not yet been reported. We confirm these predictions experimentally.
PLOS Computational Biology 9
article e1003347 (2013) pdf version
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