Mutational pathway determines whether drug gradients accelerate evolution of resistance
Supplemental material
P. Greulich, B. Waclaw and R. Allen
Animations
Animations corresponding to snapshots from Fig. 1 and
uniform drug distribution, K=100, L=500, mu=5e-6, c=0.3
non-uniform drug distribution, K=100, L=500, mu=5e-6, alpha=0.012
Animations for Fig. 3, for M=6 and
uniform drug distribution, K=100, L=300, mu=1e-4, c=0.9
non-uniform drug distribution, K=100, L=300, mu=1e-4, alpha=0.07
Text
Contains a detailed discussion of the parameters of the model, a description of computer simulations,
a derivation of the time to fixation in the uniform drug distribution, an explicit calculation of fixation
times for an exponential drug distribution and exponential MICs, and a derivation of the time to resistance
for pathways with fixed initial and final MICs and different number of intermediate mutations. Click here for a PDF file