Research Fellow Working on Topological Problems in Soft Matter and Biology
University of Edinburgh Peter Guthrie Tait Road James Clerk Maxwell Building Office 1505
davide.michieletto@ed.ac.uk
Institute of Genetics and Molecular Medicine
Gilbert group
University of Bath North Road Dept of Mathematical Sciences
A de-localised knotted state is stabilised by the action of multiple (here 2) SMC proteins. Note that the essential crossings are instead localised. Dark-grey = polymer backbone. Light-grey = extruded segments. Cyan = shortest knotted arc.
A trefoil knot is simplified through the synergistic action of SMC and Topo2
A delocalised trefoil knot on a polymer is localised by the slip-link-like protein SMC cohesin/condensin
Simulated HIV integration in a nucleosome
HIV integration in a condensed (poly-nucleosome) fibre
4D Epigenome: Transition from Swollen-Disordered to Compact-Ordered phases of chromatin.
A 7_1 knot under confinement is simplified through the synergistic action of SMC and Topo2
A delocalised Hopf link between polymers is localised by the slip-link-like protein SMC cohesin/condensin
HIV integration in an open (poly-nucleosome) fibre
HIV integration in 3D folded (left) or unfolded (right) chromosome segments
4D Epigenome with transcriptional recolouring
Transition from Stretched-Disordered to Compact-Ordered phase of a "recolourable polymer" model for a chromatin fibre with dynamic epigenome
A knotted soliton
Configuration of a ring within a dense solution. The left configuration highlights the bases of (hierarchical) loops, which are marked by coloured beads. The right configuration shows the presence of "branches" (or double-folded structures), which are marked by red beads.
Plasmids undergoing gel extrophoresis through a network of solid nanowires (Rahong et al, Sci Rep 2014). Notice the non-monotonic change in average speed for increasing values of the external electric field. Courtesy of T. Yasui.
