Selected Talks

Talk at "Topological Soft Matter" workshop, Edinburgh, May 2023
Recorded Talk

Talk on Topologically Active Polymers (17.11.2021)
Keynote speaker at the Statistical Mechanics and Thermodynamics Early Career Scientist Symposium. Event

Talk on Topologically Active Polymers (29-31.03.2021)
At the Faraday joint interest group conference 2021 Event

Talk on HIV integration (1-6.03.2021)
at Multiscale Simulation & Mathematical Modelling of Complex Biological Systems (virtual, Jawaharlal Nehru University, New Delhi, India) Speakers

Talk on Topologically Active Polymers (02.2021)
Link to recording: DNA nanotech webinar series

Talk on HIV integration (29.01.2021)
Link to recording: Sussex Biochemistry and Biomedicine seminar series

Talk on HIV integration and Topoisomerase models (01.2021)
Link to recording: Duke Mathematical Biology Seminar series

Selected Publications

For the most up-to-date list see Google Scholar


P He et al, Single-molecule structure and topology of kinetoplast dna networks, PRX 2023.

Y Fosado et al, Fluidification of Entanglements by a DNA bending protein , PRL 2023.


A Bonato et al, Topological gelation of reconnecting polymers , PNAS 2022.

J L Sleiman et al, Geometric Predictors of Knotted and Linked Arcs, ACS Polymers Au 2022.

D Michieletto et al, Dynamic and facilitated binding of topoisomerase accelerates topological relaxation , Nucleic Acids Research , 50(8), 2022.

JK Ryu et al, Condensin extrudes DNA loops in steps up to hundreds of base pairs that are generated by ATP binding events. Nucleic acids research , 50(2), 2022

M Tišma et al, ParB proteins can bypass DNA-bound roadblocks via dimer-dimer recruitment Science Advances 8(26), 2022


A Bonato and D Michieletto, Three-dimensional loop extrusion. Biophysical Journal, 120(24), 2021

Eeftens, Kapoor, Michieletto & Brangwynne. Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction , Nature Communications, 12(1), 1-12, 2021

J Smrek et al, Topological tuning of DNA mobility in entangled solutions of supercoiled plasmids, Science Advances, 7(20), 2021

M Marenda et al, Parameter-free molecular super-structures quantification in single-molecule localization microscopy, J Cell Biol, 220 (5), 2021

JK Ryu et al, Bridging-induced phase separation induced by cohesin SMC protein complexes, Science Advances, 7(7), 2021

D Michieletto and T Sakaue, Dynamical Entanglement and Cooperative Dynamics in Entangled Solutions of Ring and Linear Polymers, ACS Macro Lett., 10(1), 2021


A Rosa, J Smrek, MS Turner, D Michieletto, Threading-Induced Dynamical Transition in Tadpole-Shaped Polymers, ACS MacroLetters, 2020

D Michieletto, Non-Equilibrium Living Polymers, Entropy, 2020

A Bonato et al Chromosome compaction and chromatin stiffness enhance diffusive loop extrusion by slip-link proteins , Soft Matter, 2020

F Landuzzi, T Nakamura, D Michieletto, T Sakaue, Persistence homology of entangled rings, Physical Review Research, 2020

D Michieletto, T Sakaue, Dynamical Entanglement and Cooperative Dynamics in Entangled Solutions of Ring and Linear Polymers, ACS MacroLetters, 2020

A Bousios, H-W Nuetzmann, D Buck, D Michieletto, Integrating transposable elements in the 3D genome, Mobile DNA, 2020


M Chiang et al, Polymer modeling predicts chromosome reorganization in senescence, Cell Reports, 2019

D. Coli, D. Michieletto, D. Marenduzzo, E. Orlandini, Magnetic polymer models for epigenetics-driven chromosome folding, PRE, 2019

D. Michieletto, D. Coli, E. Orlandini, D. Marenduzzo, Non Equilibrium Theory of Epigenomic Microphase Separation in the Cell Nucleus, PRL, 2019

E. Orlandini, D. Marenduzzo, D. Michieletto, Synergy of Topoisomerase and SMC proteins Creates a Universal Pathway to Simplify Genome Topology, PNAS , 2019

D. Michieletto, M. Lusic, D. Marenduzzo, E. Orlandini, Physical Principles of Retroviral Integration in the Human Genome, Nature Communications, 10(575), 2019


R. Fitzpatrick, D. Michieletto, K. R. Peddireddy, C. Hauer, C. Kyrillos, B. J. Gurmessa, R. Robertson-Anderson, Synergistic Interactions Between DNA and Actin Trigger Emergent Viscoelastic Behavior, PRL, 121,(257801), 2018

D. Michieletto, M. Chiang, D. Colì, A. Papantonis, E. Orlandini, P. R. Cook, D. Marenduzzo, Shaping Epigenetic Memory via Genomic Bookmarking, Nucleic Acids Res., 46(1), 2018


D. Michieletto, N. Nahali, A. Rosa, Glassiness and Heterogeneous Dynamics in Dense Solutions of Ring Polymers, Phys. Rev. Lett., 119(197801), 2017

C.A. Brackley, J. Johnson, D. Michieletto, A.N. Morozov, M. Nicodemi, P.R. Cook, D. Marenduzzo, Nonequilibrium Chromosome Looping via Molecular Slip Links , Phys. Rev. Lett. 119(138101), 2017

CA Brackley et al, Ephemeral protein binding to DNA shapes stable nuclear bodies and chromatin domains, Biophysical J2017

Y. A. Fosado, D. Michieletto, D. Marenduzzo, Dynamical Scaling and Phase Coexistence in Topologically-Constrained DNA Melting, Phys. Rev. Lett., 119(118002), 2017


D. Michieletto and M. S. Turner, A Topologically Driven Glass in Ring Polymers , Proc. Natl. Acad. Sci. USA, 113(19), 2016

D. Michieletto, E. Orlandini and D. Marenduzzo, Polymer Model with Epigenetic Recolouring Reveals a Pathway for the De Novo Establishment and 3D Organization of Chromatin Domains, Phys. Rev. X, 6(041047), 2016

D. Michieletto, On the Tree-Like Structure of Rings in Dense Solutions, Soft Matter, 12, 2016


D Michieletto et al Topological patterns in two-dimensional gel electrophoresis of DNA knots , PNAS 2015

D. Michieletto, D. Marenduzzo, E. Orlandini, Is the Kinetoplast DNA a Percolating Network of Linked Rings at its Critical Point? , Phys. Biol., 12(036001), 2015

D Michieletto et al Rings in random environments: sensing disorder through topology , Soft Matter 2015


D. Michieletto, D. Marenduzzo, E. Orlandini, G. P. Alexander, M. S. Turner, Threading Dynamics of Ring Polymers in a Gel, ACS Macro Lett., 3, 2014