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Bacterial response to pressure

S. Lucas Black, a PhD student who was jointly supervised by me and my colleague Dr. Bruce Ward of the School of Biological Sciences in Edinburgh, carried out a detailed experimental study of how E. coli bacteria respond to hydrostatic pressure. Even though high pressure environments are very widespread on Earth (especially at the bottom of the ocean), very little is known about how organisms respond to pressure, compared to other stresses. Lucas's work involved screening a collection of over 4000 gene deletion mutants of E. coli (the Keio collection), to find out which genes are essential for growth at high hydrostatic pressure. He discovered that genes involved in DNA replication, cell divison, the cytoskeleton and cell enveleope physiology are particularly important for growth at pressure. This fits in well with previous work that suggests that there is not one single gene responsible for pressure-tolerance, but rather the effects of pressure on cells are pleiotropic.


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25/08/2022

Here is a great 3 minute video of our PhD student Freya Bull describing her research modelling bacterial infection of a urinary catheter!

25/08/2022

We are searching for a part-time computer systems administrator for our group in Jena. Please contact us if you are interested!

18/08/2022

Welcome to Ariane Zander who has joined us as a technician in our lab!

 
 

 

 
 
 
 
 
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